OLIVE LEAF
Benefit of olive leaf extract There have not been any good human studies with olive leaf extract to know which medical conditions it would benefit. Olive leaf extract is just beginning to be tested in humans so it may take some time until we find out the right dosage for the right condition. A study in rodents shows this herb may have blood pressure lowering effect. Anti-inflammatory benefit Most flavonoids in olive leaf extract have antiinflammatory properties Immune system Most flavonoids in olive leaf extract have anti-microbial activity. Diabetes The hypoglycemic activity of olive leaf extract was studied. One of the compounds responsible for this activity was oleuropeoside, which showed activity at a dose of 16 mg/kg. This compound also demonstrated antidiabetic activity in animals with alloxan-induced diabetes. HIV Olive leaf may have anti-HIV activity (see below). Vascular dilation Researchers studied the importance of the smooth vascular muscle endothelium in the vasodilator action of the decoction of olive leaf (Olea europaea). The decoction caused relaxation of isolated rat aorta preparations both in the presence and in the absence of endothelium. The results indicate that the relaxant activity of the lyophilized decoction is independent of the integrity of the vascular endothelium. We also showed that oleuropeoside is a component responsible for vasodilator activity but, from the results, it seems likely that at least one other principle is to be found in the olive leaf which is either a vasodilator itself or else potentiates the relaxant effect of oleuropeoside. Olive leaf extract side effects There have not been any side effects reported yet with olive leaf extract supplement, but few human studies are available. Benefit of Olive Leaf Extract Research The olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia rhabdovirus (VHSV).Antiviral Res. 2005 Jun;66(2-3):129-36. Instituto de Biologia Molecular y Celular, Universidad Miguel Hernandez, E-03202-Elche, Alicante, Spain. A commercial plant extract derived from olive tree leaf (Olea europaea) and its major compound, oleuropein, inhibited the in vitro infectivity of the viral haemorrhagic septicaemia virus (VHSV), a salmonid rhabdovirus. Incubation of virus with olive tree leaf extract or oleuropein before infection reduced the viral infectivity to 10 and 30%, respectively. Furthermore, olive tree leaf extractdrastically decreased VHSV titers and viral protein accumulation (virucidal effect) in a dose dependent manner when added to cell monolayers 36 h post-infection. On the other hand, both the olive tree leaf extract and oleuropein were able to inhibit cell-to-cell membrane fusion induced by VHSV in uninfected cells, suggesting interactions with viral envelope. Therefore, we propose that olive tree leaf extract could be used as a potential source of promising natural antivirals, which have demonstrated to lack impact on health and environment. In addition, oleuropein could be used to design other related antiviral agents. Anti-HIV activity of olive leaf extract and modulation of host cell gene expression by HIV-1 infection and olive leaf extract treatment.Lee-Huang S. ew York University School of Medicine, New YorkBiochem Biophys Res Commun. 2003 Aug 8;307(4):1029-37. We investigated the antiviral activity of olive leaf extract preparations standardized by liquid chromatography-coupled mass spectrometry (LC-MS) against HIV-1 infection and replication. We find that olive leaf extract inhibits acute infection and cell-to-cell transmission of HIV-1 as assayed by syncytia formation using uninfected MT2 cells co-cultured with HIV-1-infected H9 T lymphocytes. olive leaf extract also inhibits HIV-1 replication as assayed by p24 expression in infected H9 cells. These anti-HIV effects of olive leaf extract are dose dependent, with EC(50)s of around 0.2 microg/ml. In the effective dose range, no cytotoxicity on uninfected target cells was detected. The therapeutic index of olive leaf extract is above 5000. To identify viral and host targets for olive leaf extract, we characterized gene expression profiles associated with HIV-1 infection and olive leaf extract treatment using cDNA microarrays. HIV-1 infection modulates the expression patterns of cellular genes involved in apoptosis, stress, cytokine, protein kinase C, and hedgehog signaling. HIV-1 infection up-regulates the expression of the heat-shock proteins hsp27 and hsp90, the DNA damage inducible transcript 1 gadd45, the p53-binding protein mdm2, and the hedgehog signal protein patched 1, while it down-regulates the expression of the anti-apoptotic BCL2-associated X protein Bax. Treatment with olive leaf extract reverses many of these HIV-1 infection-associated changes. Treatment of HIV-1-infected cells with olive leaf extract also up-regulates the expression of the apoptosis inhibitor proteins IAP1 and 2, as well as the calcium and protein kinase C pathway signaling molecules IL-2, IL-2Ralpha, and ornithine decarboxylase ODC1. Blood pressure lowering effect of an olive leaf extract (Olea europaea) in L-NAME induced hypertension in rats.Arzneimittelforschung. 2002;52(11):797-802.Department of Pharmacology, Faculty of Pharmacy, Cairo University, Cairo, Egypt. A specially prepared olive leaf extract has been tested for its blood pressure lowering activity in rats rendered hypertensive by daily oral doses of L-NAME (NG-nitro-L-arginine methyl ester, 50 mg/kg) for at least 4 weeks. Oral administration of the extract at different dose levels at the same time as L-NAME for a period of 8 weeks showed a dose dependent prophylactic effect against the rise in blood pressure induced by L-NAME, best effects being induced by a dose of 100 mg/kg of the extract. In rats previously rendered hypertensive by L-NAME for 6 weeks and then treated with that dose of the extract for a further 6 weeks without discontinuation of L-NAME, normalisation of the blood pressure was observed. The findings confirm previous reports on the hypotensive effects of olive leaf extract. The special extract, EFLA 943, was shown to give consistent results with little individual variability. The antihypertensive effect of the olive leaf extract may be related to a variety of factors involving reversal of vascular changes involved in the L-NAME induced hypertension. Olive leaf extract has been tested in oral herpes.
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